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KMID : 1161420170200090882
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Journal of Medicinal Food
2017 Volume.20 No. 9 p.882 ~ p.886
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Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation
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Ramirez-Rodriguez Alejandra M.
Gonzalez-Ortiz Manuel
Martinez-Abundis Esperanza
Ortega Natalhie Acuna
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Abstract
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To evaluate the effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation, a randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (30?60 years) with a diagnosis of metabolic syndrome without treatment. They were randomly assigned to two groups of 12 patients, each to receive orally 150?mg of ursolic acid or homologated placebo once a day for 12 weeks. Before and after the intervention, the components of metabolic syndrome, insulin sensitivity (Matsuda index), and inflammation profile (interleukin-6 and C-reactive protein) were evaluated. After ursolic acid administration, the remission of metabolic syndrome occurred in 50% of patients (P?=?.005) with significant differences in body weight (75.7?±?11.5 vs. 71?±?11?kg, P?=?.002), body mass index (BMI) (29.9?+?3.6 vs. 24.9?±?1.2?kg/m2, P?=?.049), waist circumference (93?±?8.9 vs. 83?+?8.6?cm, P?=?.008), fasting glucose (6.0?±?0.5 vs. 4.7?±?0.4?mmol/L, P?=?.002), and insulin sensitivity (3.1?±?1.1 vs. 4.2?±?1.2, P?=?.003). Ursolic acid administration leads to transient remission of metabolic syndrome, reducing body weight, BMI, waist circumference and fasting glucose, as well as increasing insulin sensitivity.
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KEYWORD
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inflammation, insulin sensitivity, metabolic syndrome, ursolic acid
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